Rules and Regulations. Notice of receipt and request for comment
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/register/2026/01/05/2025-24244·A research copy — for the controlling text, always check the official state or federal source. Not legal advice.
BILLING CODE 6560-50-P ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPPT-2025-0067; FRL-12475-10-OCSPP] Certain New Chemicals; Receipt and Status Information for September and October 2025 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of receipt and request for comment. SUMMARY: This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import)
(NOC)for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers new chemical submissions that have passed an initial screening and, for PMNs, SNUNs and MCANs, were determined to be complete, during the period from 10/1/2025 to 10/31/2025. DATES: Comments must be received on or before February 4, 2026. ADDRESSES: Submit your comments, identified by docket identification
(ID)number EPA-HQ-OPPT-2025-0067 and the specific case number provided in this document for the chemical substance related to your comment, online at *https://www.regulations.gov.* Follow the online instructions for submitting comments. Do not submit electronically any information you consider to be Confidential Business Information
(CBI)or other information whose disclosure is restricted by statute. Additional instructions on commenting and visiting the docket, along with more information about dockets generally, is available at *https://www.epa.gov/dockets.* FOR FURTHER INFORMATION CONTACT: *For technical information:* Jim Rahai, Regulatory and Information Services Division (7603M), Office of Misson Critical Operations, Office of Chemical Safety and Pollution Prevention, Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-0001; telephone number:
(202)564-8593; email address: *rahai.jim@epa.gov.* *For general information:* The TSCA-Hotline, Goodwill of the Finger Lakes, 422 South Clinton Ave., Rochester, NY 14620; telephone number:
(202)554-1404; email address: *TSCA-Hotline@epa.gov.* SUPPLEMENTARY INFORMATION: I. Executive Summary A. Does this action apply to me? This action provides information that is directed to the public in general. B. What is the Agency's authority for taking this action? EPA is publishing this document in the **Federal Register** as required by sections 5 of the Toxic Substances Control Act (TSCA), 15 U.S.C. 2601 *et seq.,* and corresponding EPA regulations. Under TSCA, a chemical substance may be either an “existing” chemical substance or a “new” chemical substance, see *https://www.epa.gov/chemicals-under-tsca.* Any chemical substance that is not on EPA's TSCA Inventory of Chemical Substances (TSCA Inventory) is classified as a “new chemical substance,” while a chemical substance that is listed on the TSCA Inventory is classified as an “existing chemical substance.” See TSCA section 3(2) and (11). For more information about the TSCA Inventory, see *https://www.epa.gov/inventory.* Any person who intends to manufacture (including import) a new chemical substance for a non-exempt commercial purpose, or to manufacture or process a chemical substance in a non-exempt manner for a use that EPA has determined is a significant new use, is required by TSCA section 5 to provide EPA with a PMN, MCAN, or SNUN, as appropriate, before initiating the activity. EPA will review the notice, make a risk determination on the new chemical substance or significant new use, and take appropriate action as described in TSCA section 5(a)(3). TSCA section 5(h)(1) authorizes EPA to allow persons, upon application and under appropriate restrictions, to manufacture a new chemical substance, or manufacture or process a chemical substance subject to a significant new use rule
(SNUR)issued under TSCA section 5(a)(2), for “test marketing” purposes, upon a showing that the manufacture, processing, distribution in commerce, use, and disposal of the chemical substances will not present an unreasonable risk of injury to health or the environment. This is referred to as a test marketing exemption, or TME. Premanufacture notification procedures for review of certain new microbial products of biotechnology are established in 40 CFR part 725. These pertain to MCANs and biotechnology exemptions, including TSCA experimental release applications (TERAs), TMEs for microorganisms, and Tier I and Tier II exemptions. C. What action is the Agency taking? This document provides notice of receipt and status reports for the covered period and certain submissions under TSCA section 5 and provides an opportunity to comment on this information. The Agency is providing information about the receipt of PMNs, SNUNs, MCANs, and amendments to a previously submitted notice; test information; biotechnology exemption applications under 40 CFR part 725; TME applications; NOCs for new chemical substances; and a periodic status report on chemical substances that are currently under EPA review or have recently concluded review. D. What should I consider as I prepare my comments for EPA? 1. *Submitting CBI.* Do not submit CBI to EPA through *https://www.regulations.gov* or email. If you wish to include CBI in your comment, please follow the instructions at *https://www.epa.gov/dockets/commenting-epa-dockets#rules* and clearly mark the information that you claim to be CBI. In addition to one complete version of the comment that includes CBI, a copy of the comment without CBI must be submitted for inclusion in the public docket. Information marked as CBI will not be disclosed except in accordance with procedures set forth in 40 CFR parts 2 and 703. 2. *Tips for preparing your comments.* When preparing and submitting your comments, see the commenting tips at *https://www.epa.gov/dockets/commenting-epa-dockets.* II. Background A. What information is being provided in this document? The tables in this document provide the following information on the TSCA section 5 submissions received by EPA during this period and determined to be complete consistent with 40 CFR 720.70(a). • *Case number.* The EPA number assigned to the TSCA section 5 submissions. Please note that a case number may be listed more than once in the table when the submission involves a subsequent amendment. • *Chemical substance.* Name of the chemical substance, or generic name if the specific name is claimed as CBI. • *Manufacturer.* Name of the submitting manufacturer, to the extent that such information is not subject to a CBI claim. The term “manufacturer” is defined by statute to include importer. • *Use(s).* Potential uses identified by the manufacturer. • *Received.* Date the submission was received by EPA. • *Commencement.* Date of commencement provided by the submitter in the NOC. • *Test information.* For test information received, the type of test information submitted to EPA based on the attachment type and subtype data selected by the submitter. B. What do the acronyms mean that are used in the tables? As used in each of the tables, the following explanations apply: •
(S)indicates that the information in the table is the specific information provided by the submitter. •
(G)indicates that the information in the table is generic information because the specific information provided by the submitter was claimed as CBI. C. How can I access other information about TSCA section 5 submissions? EPA provides information on its website about cases reviewed under TSCA section 5, including the PMNs, SNUNs, MCANs, and exemption applications received; the date of receipt; the final EPA determination on the submission; and the effective date of EPA's determination. See *https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca/status-pre-manufacture-notices.* In addition, information EPA receives about chemical substances under TSCA, including non-CBI new chemical submissions, can be accessed in ChemView at *https://chemview.epa.gov/chemview.* III. Receipt Reports Table 1 provides non-CBI information for the PMNs, SNUNs and MCANs received by EPA that have passed an initial screening and determined to be complete consistent with 40 CFR 720.70(a) during this period. Table 1—PMN/SNUN/MCANs Received and Under Review Case No. Received date Manufacturer Use Chemical substance J-25-0015 09/16/2025 Danisco US, Inc
(G)Production of a chemical substance
(G)Genetically modified microorganism. P-23-0162 10/21/2025 CBI
(S)Transportation fuels, Chemical Feedstock, Fuel additive
(G)Alkane (glyceridic), hydrotreated and isomerized. P-23-0163 10/02/2025 CBI
(G)Surface coating
(S)1,2-Ethanediamine, N1-[3-(trimethoxysilyl) propyl]-, hydrolysis products with 3-(trimethoxysilyl)-N- [3- (trimethoxysilyl)propyl]-1-propanamine, nitrates (salts). P-24-0043 10/06/2025 Clariant Corporation
(S)Catalyst for use in petrochemical operations
(S)Iron potassium oxide (FeKO2). P-24-0093 10/24/2025 Evonik Corporation
(S)Surfactant in manual/hand dish, laundry detergent, and hard surface cleaner
(G)Rhamnolipids, modified pseudomonas-fermented, from dextrose, salts. P-24-0094 10/24/2025 Evonik Corporation
(S)Surfactant in manual/hand dish, laundry detergent, and hard surface cleaner
(G)Rhamnolipids, modified pseudomonas-fermented, from dextrose, salts. P-24-0095 10/24/2025 Evonik Corporation
(S)Surfactant in manual/hand dish, laundry detergent, and hard surface cleaner
(G)Rhamnolipids, modified pseudomonas-fermented, from dextrose, salts. P-24-0096 10/24/2025 Evonik Corporation
(S)Surfactant in manual/hand dish, laundry detergent, and hard surface cleaner
(G)Rhamnolipids, modified pseudomonas-fermented, from dextrose, salts. P-24-0115 10/17/2025 PCI Synthesis
(S)Additive ( *e.g.,* solvent, cleaning agent, coalescent) used in spray-applied products ( *e.g.,* paints, coatings, inks, toner), and non-spray applied products ( *e.g.,* adhesives, sealants, thinners, paint removers, anti-freeze and de-icing products, fillers, putties, plasters, clays, tableting, compression, extrusion, palletization, granulation, surface treatment, leather treatment, lubricants, greases, waxes, polishes, release products, degreasers)
(S)Pentanedioic acid, 1,5-dibutyl ester. P-25-0093 10/08/2025 CBI
(G)Battery Component
(G)Mixed Metal Oxide. P-25-0094 10/08/2025 CBI
(G)Battery Component
(G)Mixed Metal Oxide. P-25-0095 10/08/2025 CBI
(G)Battery Component
(G)Mixed Metal Oxide. P-25-0096 10/08/2025 CBI
(G)Battery Component
(G)Mixed Metal Oxide. P-25-0129 10/09/2025 Hawkins, Inc
(S)Correction of iron deficiency in alkaline soils when EDTA-Fe is not stable. Product is intended as a fertilizer micronutrient
(S)Ferrate (3-), [[a, a′-[1,2-ethanediyldi(imino-kN)] bis[2-(hydroxy-kO)-5-sulfobenzeneacetato-kO]] (6-)]-, sodium (1:3). P-25-0135 10/22/2025 CBI
(G)Used as a component in battery manufacturing
(G)Metal- and metal- and metal-doped cobalt lithium manganese nickel oxide. P-25-0136 10/22/2025 CBI
(G)Used as a component in battery manufacturing
(G)Metal- and metal-doped cobalt lithium manganese nickel oxide. P-25-0157 10/21/2025 Quino Energy
(S)Active material (electrolyte) in redox flow batteries, serving as the battery's negolyte (also referred to as the anolyte) for electrical energy storage applications
(S)2,6-Anthracenediacetic acid, 9,10-dihydro-1,5-dihydroxy-9,10-dioxo-, potassium sodium salt (1:?:?). P-26-0001 10/08/2025 CBI
(S)Chemical Intermediate
(G)Propenoic acid, -methyl, -[alkylsiloxanyl]propyl ester. P-26-0003 10/08/2025 Bedoukian Research, Inc
(S)Site-limited intermediate
(G)3-Acetoxyalkyltriarylphosphonium bromide. P-26-0004 10/08/2025 Bedoukian Research, Inc
(S)Site-limited intermediate
(G)8-Acetoxyalkyltriarylphosphonium bromide. P-26-0005 10/08/2025 Bedoukian Research, Inc
(S)Site-limited intermediate
(G)9-Acetoxyalkyltriarylphosphonium bromide. P-26-0007 10/15/2025 Brewer Science, Inc
(G)Ingredient used in coating solution
(G)Carbomonocyclic sulfonium salt. P-26-0007 10/21/2025 Brewer Science, Inc
(G)Ingredient used in coating solution
(G)Carbomonocyclic sulfonium salt. P-26-0008 10/16/2025 CBI
(S)Used as a fragrance ingredient in consumer products
(G)6-Nonen-1-ol, methyl substituted. P-26-0009 10/17/2025 CBI
(G)Electrolyte additive
(G)Carbonic acid, methyl alkyl ester. P-26-0011 10/21/2025 Clariant Corporation
(S)Catalyst for use in petrochemical operations
(G)Metal oxide. P-26-0012 10/24/2025 Nabors Energy Transition Solutions—Tomball
(G)Additive to enhance material characteristics and performance
(G)Mixture of carbon nanomaterials—Type A. P-26-0013 10/24/2025 Nabors Energy Transition Solutions—Tomball
(G)Additive to enhance material characteristics and performance
(G)Mixture of carbon nanomaterials—Type B. P-26-0014 10/24/2025 CBI
(G)Additive used in industrial applications
(G)Polyheterocycle, polyatom, Heterocycle-heterocycle, polyatom, polyatom, Heterocycle-heterocycle, polyatom, polyatom,. P-26-0015 10/28/2025 CBI
(G)Use in inks/coatings
(S)2-Propenoic acid, (2,2-dimethyl-1,3-dioxolan-4-yl) methyl ester;2-Propenoic acid, 2,2-dimethyl-1,3-dioxan-5-yl ester. P-26-0016 10/29/2025 CBI
(G)Additive in Household consumer products
(S)Benzene, 1-methoxy-4-[3-methyl-4-(2-phenylethoxy)-3-buten-1-yl]-. SN-21-0008 10/24/2025 CBI
(S)Heat transfer system, Foam expansion agent
(G)Test media, Specialty fluid, Clean agent system
(S)2-Butene, 1,1,1,4,4,4-hexafluoro-, (2Z)-. SN-21-0009 10/24/2025 CBI
(G)Not Applicable
(S)2-Butene, 1,1,1,4,4,4-hexafluoro-, (2E)-. Table 2 provides non-CBI information on the NOCs received by EPA that have passed an initial screening during this period. Table 2—NOCs Received and Under Review Case No. Received date Commencement date Chemical substance J-22-0007 10/03/2025 09/25/2025
(G)Strain of Escherichia coli modified with genetically stable, plasmid-borne DNA for the production of plasmid-borne DNA. J-25-0004 10/01/2025 09/09/2025
(G)Modified yeast, with chromosomal modifications to improve fermentation characteristics. P-18-0325 10/22/2025 10/06/2025
(G)Benzenesulfonic acid, alkyl derivs., compds. with diisopropanolamine. P-21-0075 10/15/2025 10/12/2025
(G)Alkanoic acid, hydroxy-(hydroxyalkyl)-alkyl-, polymer with alpha-[(hydroxyalkyl)alkyl]-omega-alkoxypoly(oxy-alkanediyl), dialkyl carbonate, alkanediol, alkylene[isocyanato-carbomonocycle] and [oxybis(alkylene)] bis[alkyl-alkanediol] alkenoate, compd. with dialky alkanamine. P-21-0080 10/15/2025 10/12/2025
(G)Alkanedioic acid, polymers with alkanoic acid-dipentaerythritol reaction products, substituted alkanedioc acid, substituted alkanoic acid, isocyanato-(isocyanatoalkyl)-alkyl substituted carbomoncycle, dialkyl alkanediol and polyalkylene glycol(hydroxyalkyl)alkyl aklyl ether. P-22-0002 10/17/2025 08/05/2025
(G)Molybdenum chloride oxide (MoCl2O2), (T-4)-. P-22-0145 10/06/2025 09/07/2025
(G)Alkanoic acid, trialkyl-, diester with carbomonocycle bis(alkyleneoxy)] bis[alkanediol]. P-23-0047 09/30/2025 09/01/2025
(G)Heteromonocyclic, dialkyl amide, substituted alkyl salt. P-23-0072 10/20/2025 09/30/2025
(G)Halosubstituted carbopolycycle, polymer with substituted carbomonocycles and oxybis[alkanol]. P-23-0078 10/30/2025 10/06/2025
(S)Soybean oil, polymer with diethylene glycol- and glycerol- and tetraethylene glycol- and triethylene glycoldepolymd.poly(ethylene terephthalate) waste plastics, 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid and phthalic anhydride. P-24-0082 10/21/2025 09/30/2025
(S)2-propenoic acid, 3-bromo-2,2-bis(bromomethyl)propyl ester. P-24-0102 10/03/2025 10/02/2025
(G)Polyester polymer with polyether polymer and 1,1′-methylenebis[4-isocyanatobenzene]. P-24-0103 10/06/2025 10/05/2025
(G)Polyester polymer with polyether polymer and 1,1′-methylenebis[isocyanatobenzene]. P-24-0161 10/01/2025 08/17/2025
(S)Fats and glyceridic oils, camelina sativa. P-25-0070 10/21/2025 09/30/2025 (G)Sulfonium, is (dihalo carbomonocycle)(halo carbomonocycle)-, salt with dihalo-sulfoalkyl [(alkenylcarbomonocycle)substituted] trisubstituted benzoate, polymer with alkenylcarbomonocycle and alkylcarbomonocycle alkyl alkenoate. P-25-0071 10/21/2025 09/30/2025 (G)Sulfonium, is (dihalo carbomonocycle) (halocarbomonocycle)-, salt with trihalobenzoate. Table 3 provides non-CBI information on the test information that has been received by EPA that have passed an initial screening during this period. Table 3—Test Information Received Case No. Received date Type of test information Chemical substance P-08-0200 10/24/2025 Analytical summary
(G)Partially fluorinated amphiphilic condensation polymer. P-08-0200 10/25/2025 Analytical summary
(G)Partially fluorinated amphiphilic condensation polymer. P-08-0200 10/29/2025 Analytical summary
(G)Partially fluorinated amphiphilic condensation polymer. P-08-0642 10/24/2025 Analytical Summary
(G)Fluorinated acrylic copolymer. P-08-0643 10/24/2025 Analytical Summary
(G)Fluorinated acrylic copolymer. P-08-0644 10/24/2025 Analytical Summary
(G)Fluorinated acrylic copolymer. P-08-0664 10/24/2025 Analytical Summary
(G)Fluorinated acrylic copolymer. P-08-0748 10/27/2025 Analytical Summary
(G)Fluorinated acrylic copolymer. P-08-0751 10/27/2025 Analytical Summary
(G)Fluorinated acrylic copolymer. P-09-0245 10/27/2025 Analytical Summary
(G)Partially fluorinated alcohol, reaction products with phosphorus oxide (P205), ammonium salts. P-09-0246 10/27/2025 Analytical Summary
(G)Partially fluorinated alcohol, reaction products with phosphorus oxide (P205). P-09-0293 10/27/2025 Analytical Summary
(G)Phosphoric acid, mixed esters with partially fluorinated alcohol, ammonium salts. P-09-0294 10/27/2025 Analytical Summary
(S)Phosphoric acid, mixed esters with polyethylene glycol and 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanol, ammonium salts. P-10-0058 10/27/2025 Analytical Summary
(G)Partially fluorinated alcohol substituted glycol. P-10-0059 10/27/2025 Analytical Summary
(G)Partially fluorinated alcohol substituted glycol. P-10-0060 10/27/2025 Analytical Summary
(G)Partially fluorinated alcohol substituted glycol. P-11-0091 10/27/2025 Annual Report
(G)Fluorinated acrylic alkylamino copolymer. P-11-0526 10/24/2025 Annual Report
(G)Amphoteric fluorinated surfactant. P-12-0450 10/27/2025 Annual Report
(G)Partially fluorinated alcohol, reaction products with phosphorus oxide (P2O5), amine salts. P-14-0712 10/03/2025 Test Results
(S)Waste plastics, pyrolyzed, C5-55 fraction. P-14-0712 10/14/2025 Analytical Report
(S)Waste plastics, pyrolyzed, C5-55 fraction. P-17-0178 10/18/2025 Study Report
(G)Sulfonium, triphenyl-, salt with substituted-alkyl 4-substituted-benzoate. P-18-0016 10/01/2025 Study Report
(G)Aromatic sulfonium tricyclo fluoroalkyl sulfonic acid salt. P-20-0042 09/29/2025 Study Report
(G)Sulfonium, trisaryl-, 7,7-dialkyl-2-heteropolycyclic -1-alkanesulfonate (1:1). P-20-0141 10/20/2025 Study Report
(G)Sulfonium, [4-(1,1-dimethylethyl) phenyl] diphenyl-, salt with heterosubstituted-alkyl tricycloalkane-carboxylate (1:1). P-22-0042 10/27/2025 OECD No. 422-Combined repeat dose-oral toxicity study with reproduction/developmental toxicity screening in rats
(G)Alkanediones, [[[(substituted)aryl] thio] aryl]-, 2-(O-acetyloxime). P-22-0055 09/29/2025 Study Report
(G)Aromatic sulfonium tricyclo fluoroalkyl sulfonic acid salt. P-24-0044 10/02/2025 Study Report
(G)Oxirane, 2-methyl-, polymer with oxirane, ether with N-[4-[[4-[bis(2-hydroxyethyl) amino] phenyl] (2-substitutedphenyl) methylene]-2,5-cyclohexadien-1-ylidene]-2-hydroxy-N-(2-hydroxyethyl) ethanaminium inner salt (4:1). P-25-0016 09/29/2025 Study Report
(G)Tri haloaromatic iodonium dicyclo salt with polyhaloalkyl carbomonocycle hetero acid. P-25-0097 10/01/2025 Study Report
(G)Aromatic sulfonium tricyclo salt with dicocoalkyl carbomonocycle hetero acid. IV. Status Reports Information about the TSCA section 5 PMNs, SNUNs, MCANs, and exemption applications received, including the date of receipt, the status of EPA's review, the final EPA determination, and the effective date of EPA's determination, is available online at: *https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca/pre-manufacture-notices* . (Authority: 15 U.S.C. 2601 *et seq.* ) Dated: December 18, 2025. Mary Elissa Reaves, Director, Office of Pollution Prevention and Toxics. [FR Doc. 2025-24244 Filed 1-2-26; 8:45 am]
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- 40 CFR 725
- 40 CFR 720.70(a)
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Rules and Regulations
Notice of receipt and request for comment
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